methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine

Base Information

Chemical Name:methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine
CAS No.:725682-24-6
Molecular Formula:C₂₄H₃₂N₄O
Molecular Weight:392.544
Hs Code.:

methyl-(2-{5-[2-(4-<i>o</i>-tolyl-piperazin-1-yl)-ethoxy]-1<i>H</i>-indol-3-yl}-ethyl)-amine

Synonyms:methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine

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Chemical Property of methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine

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Technology Process of methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine

There total 4 articles about methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 174021-76-2
(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-carbamic acid tert-butyl ester

: 725682-24-6
methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 60 ℃;

Reference yield:

: 39512-51-1
1-(o-toluyl)piperazine

: 725682-24-6
methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / K₂CO₃; KI / dimethylformamide / 100 °C

2: 90 percent / LAH / tetrahydrofuran / 60 °C

With lithium aluminium tetrahydride; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Substitution / 2: Reduction;

Reference yield:

: 53157-48-5
tert-butyl 2-(5-hydroxy-1H-indol-3-yl)ethylcarbamate

: 725682-24-6
methyl-(2-{5-[2-(4-o-tolyl-piperazin-1-yl)-ethoxy]-1H-indol-3-yl}-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / K₂CO₃ / butan-2-one / 95 °C

2: 75 percent / K₂CO₃; KI / dimethylformamide / 100 °C

3: 90 percent / LAH / tetrahydrofuran / 60 °C

With lithium aluminium tetrahydride; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; butanone; 1: Condensation / 2: Substitution / 3: Reduction;