(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Base Information

Chemical Name:(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride
CAS No.:1443538-48-4
Molecular Formula:C₁₀H₁₁ClFN*ClH
Molecular Weight:236.116
Hs Code.:
Mol file:1443538-48-4.mol

Synonyms:(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Suppliers and Price of (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidineHydrochloride
10mg
$ 540.00

TRC
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidineHydrochloride
5mg
$ 295.00

Crysdot
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidinehydrochloride 97%
250mg
$ 275.00

Crysdot
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidinehydrochloride 97%
1g
$ 688.00

Chemenu
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidinehydrochloride 97%
1g
$ 650.00

Ambeed
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidinehydrochloride 97%
1g
$ 525.00

Ambeed
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidinehydrochloride 97%
250mg
$ 203.00

Ambeed
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidinehydrochloride 97%
100mg
$ 120.00

Alichem
(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidinehydrochloride
1g
$ 695.00

Total 8 raw suppliers

Chemical Property of (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Chemical Property:

Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

99.00% ^*data from raw suppliers

(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (R)-2-(2-Chloro-5-fluorophenyl)pyrrolidine Hydrochloride is used in the preparation of tropomyosin receptor kinase A ((TrkA) inhibitors.

Technology Process of (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

There total 1 articles about (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443538-48-4
(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 - 35 ℃; for 4h;

Reference yield:

: 885276-93-7
ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate

: 1443538-48-4
(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

: 1443538-72-4
(R)-ethyl 5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 885276-93-7
ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate

: 1443538-48-4
(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

: 1443538-73-5
(R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

2: caesium carbonate; palladium diacetate; XPhos; potassium iodide / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium iodide; XPhos; In 1,4-dioxane;