(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Base Information

• Chemical Name: (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride
• CAS No.: 1443538-48-4
• Molecular Formula: C₁₀H₁₁ClFN*ClH
• Molecular Weight: 236.116
• Mol file: 1443538-48-4.mol

Synonyms:(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Chemical Property of (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95-99% ^*data from raw suppliers

(R)-2-(2-Chloro-5-fluorophenyl)pyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (R)-2-(2-Chloro-5-fluorophenyl)pyrrolidine Hydrochloride is used in the preparation of tropomyosin receptor kinase A ((TrkA) inhibitors.

Technology Process of (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

There total 1 articles about (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride (1443538-48-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 - 35 ℃; for 4h;

Reference yield:

ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate (885276-93-7) + (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride (1443538-48-4) → (R)-ethyl 5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate (1443538-72-4)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate (885276-93-7) + (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride (1443538-48-4) → (R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate (1443538-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

2: caesium carbonate; palladium diacetate; XPhos; potassium iodide / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium iodide; XPhos; In 1,4-dioxane;

Downstream raw materials:

(R)-ethyl 5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

(R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Refernces

• 1、 -. "SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS". Page/Page column 59; 68-69. . Retrieved 2013/07/05.