(R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

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Chemical Name:(R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate
CAS No.:1443538-73-5
Molecular Formula:C₂₆H₂₃F₂N₃O₂
Molecular Weight:447.484
Hs Code.:

Synonyms:(R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

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Chemical Property of (R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

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Technology Process of (R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

There total 2 articles about (R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443538-72-4
(R)-ethyl 5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

: 1765-93-1
4-fluoroboronic acid

: 1443538-73-5
(R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; potassium iodide; XPhos; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 885276-93-7
ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate

: 1443538-48-4
(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride

: 1443538-73-5
(R)-ethyl 5-(2-(4,4'-difluoro-[1,1'-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

2: caesium carbonate; palladium diacetate; XPhos; potassium iodide / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium iodide; XPhos; In 1,4-dioxane;