3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Base Information

• Chemical Name: 3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide
• CAS No.: 1316066-19-9
• Molecular Formula: C₁₁H₁₁ClN₄O₂S
• Molecular Weight: 298.753
• Mol file: 1316066-19-9.mol

Synonyms:3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Chemical Property of 3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of 3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

There total 1 articles about 3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide (1316066-19-9)

Guidance literature:

Reference yield: 93.0%

3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide (1316066-19-9) + m-Bromoaniline (591-19-5) → 3-({6-[(3-bromophenyl)amino]-4-pyrimidinyl}amino)-N-methylbenzenesulfonamide (1316055-75-0)

Guidance literature:

3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide; m-Bromoaniline; With hydrogenchloride; In i-Amyl alcohol; for 6h; Reflux;

With ammonium hydroxide; In i-Amyl alcohol; water; Cooling;

Reference yield: 85.0%

3-((6-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide (1316066-19-9) + 2-methoxy-phenylamine (90-04-0) → N-methyl-3-[(6-{[2-(methoxy)phenyl]amino}-4-pyrimidinyl)-amino]benzenesulfonamide

Guidance literature:

With hydrogenchloride; In water; at 150 ℃; Microwave irradiation;

DOI:10.1021/acs.jmedchem.8b00125

Downstream raw materials:

3-({6-[(3-bromophenyl)amino]-4-pyrimidinyl}amino)-N-methylbenzenesulfonamide