(E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester

Base Information

• Chemical Name: (E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester
• CAS No.: 150932-52-8
• Molecular Formula: C₂₅H₃₉N₂O₃P
• Molecular Weight: 446.57

Synonyms:(E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester

Chemical Property of (E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester

There total 2 articles about (E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

tert-butyl cinnamate (14990-09-1) + (3aR,7aR)-2-allyloctahydro-1H-1,3-dimethyl-1,3,2-benzadiazaphosphole 2-oxide (146098-95-5) + methyl iodide (74-88-4) → (E)-(2S,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester + (E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester (150932-52-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jo000388g

Reference yield:

tert-butyl cinnamate (14990-09-1) + (3aR,7aR)-2-allyloctahydro-1H-1,3-dimethyl-1,3,2-benzadiazaphosphole 2-oxide (146098-95-5) + methyl iodide (74-88-4) → (E)-(2S,3R)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester + (E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester (150932-52-8)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction;

DOI:10.1021/jo00071a004

Reference yield:

(E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester (150932-52-8) → (2R,3S)-5-Hydroxy-2-methyl-3-phenyl-pentanoic acid tert-butyl ester

Guidance literature:

With ozone; Multistep reaction; 1.) CH₂Cl₂, -78 deg C;

DOI:10.1021/jo00071a004

upstream raw materials:

tert-butyl cinnamate

(3aR,7aR)-2-allyloctahydro-1H-1,3-dimethyl-1,3,2-benzadiazaphosphole 2-oxide

methyl iodide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 150932-52-8 (E)-(2R,3S)-6-((3aR,7aR)-1,3-Dimethyl-2-oxo-octahydro-2λ⁵-benzo[1,3,2]diazaphosphol-2-yl)-2-methyl-3-phenyl-hex-5-enoic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send