6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine

Base Information

Chemical Name:6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine
CAS No.:866584-79-4
Molecular Formula:C₁₅H₁₅N₅O₂S
Molecular Weight:329.382
Hs Code.:

6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-<i>d</i>]pyrimidin-4-ylamine

Synonyms:6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine

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Chemical Property of 6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine

Chemical Property:

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Technology Process of 6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine

There total 8 articles about 6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866584-33-0
[6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-yl]-carbamic acid tert-butyl ester

: 866584-79-4
6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jm050458h

Reference yield:

: 605661-10-7
2-[1-(4-nitrophenyl)propylidene]malononitrile

: 866584-79-4
6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

2.1: 93 percent / 17 h / 155 °C

3.1: NaH / tetrahydrofuran / 0.17 h / 0 °C

3.2: 63 percent / tetrahydrofuran / 2 h / 0 °C

4.1: N-bromosuccinimide; AIBN / benzene / 3 h / 80 °C

5.1: dimethylformamide / 20 °C

6.1: TFA / CH₂Cl₂ / 1.5 h / 0 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; sulfur; diethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: Gewald reaction;
DOI:10.1021/jm050458h

Reference yield:

: 605661-11-8
2-amino-5-methyl-4-(4-nitrophenyl)thiophene-3-carbonitrile

: 866584-79-4
6-dimethylaminomethyl-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-4-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / 17 h / 155 °C

2.1: NaH / tetrahydrofuran / 0.17 h / 0 °C

2.2: 63 percent / tetrahydrofuran / 2 h / 0 °C

3.1: N-bromosuccinimide; AIBN / benzene / 3 h / 80 °C

4.1: dimethylformamide / 20 °C

5.1: TFA / CH₂Cl₂ / 1.5 h / 0 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm050458h