18-acetoxy-25-hydroxyvitamin D₃

Base Information

Chemical Name:18-acetoxy-25-hydroxyvitamin D₃
CAS No.:140927-92-0
Molecular Formula:C₂₉H₄₆O₄
Molecular Weight:458.682
Hs Code.:

18-acetoxy-25-hydroxyvitamin D<sub>3</sub>

Synonyms:18-acetoxy-25-hydroxyvitamin D₃

Suppliers and Price of 18-acetoxy-25-hydroxyvitamin D₃

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Chemical Property of 18-acetoxy-25-hydroxyvitamin D₃

Chemical Property:

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Technology Process of 18-acetoxy-25-hydroxyvitamin D₃

There total 8 articles about 18-acetoxy-25-hydroxyvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 140928-02-5
18-acetoxy-25-<(trimethylsilyl)oxy>vitamin D3 tert-butyldimethylsilyl ether

: 140927-92-0
18-acetoxy-25-hydroxyvitamin D₃

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jo00037a046

Reference yield:

: 33813-99-9
Grundmann's alcohol

: 140927-92-0
18-acetoxy-25-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation

2: 1.) BF₃*Et₂O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h

3: 73 percent / K₂CO₃ / methanol / 1 h / Ambient temperature

4: 37 percent / RuCl₃*H₂O, NaIO₄ / acetonitrile; CCl₄ / 60 h / 45 °C / aq. phosphate buffer (pH 7)

5: 86 percent / tetrahydrofuran / 1.5 h

6: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 2.) THF, -78 deg C

7: 61 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature

With pyridine; lead(IV) acetate; ruthenium trichloride; sodium periodate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; methanol; tetrachloromethane; acetonitrile; benzene;
DOI:10.1021/jo00037a046

Reference yield:

: 66251-18-1
Grundmann's ketone

: 140927-92-0
18-acetoxy-25-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / LiAlH₄ / diethyl ether

2: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation

3: 1.) BF₃*Et₂O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h

4: 73 percent / K₂CO₃ / methanol / 1 h / Ambient temperature

5: 37 percent / RuCl₃*H₂O, NaIO₄ / acetonitrile; CCl₄ / 60 h / 45 °C / aq. phosphate buffer (pH 7)

6: 86 percent / tetrahydrofuran / 1.5 h

7: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 2.) THF, -78 deg C

8: 61 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature

With pyridine; lead(IV) acetate; ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; acetonitrile; benzene;
DOI:10.1021/jo00037a046