ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

Base Information

Chemical Name:ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride
CAS No.:1428526-92-4
Molecular Formula:C₁₆H₁₉FNO₂P*ClH
Molecular Weight:343.765
Hs Code.:

Synonyms:ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

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Chemical Property of ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

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Technology Process of ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

There total 9 articles about ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1428526-91-3
C₂₁H₂₇FNO₄P

: 1428526-92-4
ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 1428526-92-4
ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 3 h / 20 °C

2.1: aluminum (III) chloride / Inert atmosphere; Reflux

3.1: 24 h / 185 °C

4.1: potassium hydroxide / methanol

5.1: triethylamine / dichloromethane / 0 °C

5.2: 0 - 20 °C

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1016749-24-8
(4-bromophenyl)(4-fluorophenyl)methanamine

: 1428526-92-4
ethyl 4-(amino(4-fluorophenyl)methyl)phenyl(methyl)phosphinate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 0 - 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;