4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

Base Information

Chemical Name:4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid
CAS No.:1428526-94-6
Molecular Formula:C₂₂H₁₉FN₅O₄P
Molecular Weight:467.396
Hs Code.:

Synonyms:4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

Suppliers and Price of 4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

There total 11 articles about 4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1428526-93-5
ethyl 4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinate

: 1428526-94-6
4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 1h;

Reference yield:

: 2069-41-2
(4-bromophenyl)-(4-fluorophenyl)methanone

: 1428526-94-6
4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 24 h / 185 °C

2.1: potassium hydroxide / methanol

3.1: triethylamine / dichloromethane / 0 °C

3.2: 0 - 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: triethylamine; HATU / acetonitrile / 0.08 h / 20 °C

6.2: 1 h / 20 °C

7.1: sodium hydroxide / 1,4-dioxane / 1 h / 80 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; HATU; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 1428526-94-6
4-((4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 3 h / 20 °C

2.1: aluminum (III) chloride / Inert atmosphere; Reflux

3.1: 24 h / 185 °C

4.1: potassium hydroxide / methanol

5.1: triethylamine / dichloromethane / 0 °C

5.2: 0 - 20 °C

6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

8.1: triethylamine; HATU / acetonitrile / 0.08 h / 20 °C

8.2: 1 h / 20 °C

9.1: sodium hydroxide / 1,4-dioxane / 1 h / 80 °C

With hydrogenchloride; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; triethylamine; HATU; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;