2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

Base Information

Chemical Name:2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid
CAS No.:549494-28-2
Molecular Formula:C₂₆H₂₈O₇S₂
Molecular Weight:516.636
Hs Code.:

Synonyms:2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

Suppliers and Price of 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

There total 9 articles about 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 549494-38-4,817642-84-5,817642-85-6
methyl 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoic acid

: 549494-28-2
2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

Guidance literature:: methyl 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoic acid; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In water;

Reference yield:

: C₃₂H₄₄O₇S₂Si₂

: 549494-28-2
2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; toluene;

Reference yield:

: 549494-35-1
methyl 2-chloro-3-(4-[2-(4-hydroxyphenoxy)ethyl]phenyl)propanoate

: 549494-28-2
2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / -20 - 20 °C

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 °C

3: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 18 h

4: lithium hydroxide; water / tetrahydrofuran / 24 h / 20 °C

With lithium hydroxide; dimethylsulfide; boron trifluoride diethyl etherate; water; potassium carbonate; triethylamine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane;