7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile

Base Information

Chemical Name:7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile
CAS No.:858946-65-3
Molecular Formula:C₂₉H₃₈FNO₂Si₂
Molecular Weight:507.796
Hs Code.:

Synonyms:7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile

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Chemical Property of 7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile

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Technology Process of 7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile

There total 7 articles about 7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6836-19-7
7-Methoxy-1-tetralone

: 858946-65-3
7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: ZnI₂ / benzene / 20 °C

1.2: POCl₃; pyridine / benzene / 6 h / Heating

2.1: p-cymene / Pd/C / Heating

3.1: 0.88 g / C₆H₅N*HCl / 2 h / 190 °C

4.1: Br₂; acetic acid / 6 h / 100 °C

4.2: aq. HCl; SnCl₂ / 1 h / 100 °C

5.1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

6.1: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

7.1: 7.68 g / imidazole / dimethylformamide

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylisopropylbenzene; C₆H₅N*HCl; bromine; sodium carbonate; acetic acid; zinc(II) iodide; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; benzene; 5.1: Suzuki coupling;
DOI:10.1021/jm058173s

Reference yield:

: 158365-53-8
7-methoxy-3,4-dihydronaphthalene-1-carbonitrile

: 858946-65-3
7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: p-cymene / Pd/C / Heating

2.1: 0.88 g / C₆H₅N*HCl / 2 h / 190 °C

3.1: Br₂; acetic acid / 6 h / 100 °C

3.2: aq. HCl; SnCl₂ / 1 h / 100 °C

4.1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

5.1: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

6.1: 7.68 g / imidazole / dimethylformamide

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylisopropylbenzene; C₆H₅N*HCl; bromine; sodium carbonate; acetic acid; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/jm058173s

Reference yield:

: 550998-30-6
3-bromo-7-hydroxy-1-cyanonaphthalene

: 858946-65-3
7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

2: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

3: 7.68 g / imidazole / dimethylformamide

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; C₆H₅N*HCl; sodium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm058173s