(2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Base Information

Chemical Name:(2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine
CAS No.:1632122-24-7
Molecular Formula:C₃₁H₃₇NO₃Si
Molecular Weight:499.725
Hs Code.:

Synonyms:(2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

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Chemical Property of (2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

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Technology Process of (2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

There total 3 articles about (2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1632122-20-3
C₁₅H₁₇NO₄

: 1632122-24-7
(2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

2: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran

3: silica gel / tetrahydrofuran

With n-butyllithium; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340107

Reference yield:

: 1431853-29-0
(2S,3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

: 1632122-24-7
(2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydride; tert.-butylhydroperoxide; tetrabutyl ammonium fluoride / N,N-dimethyl-formamide

2: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

3: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran

4: silica gel / tetrahydrofuran

With tert.-butylhydroperoxide; n-butyllithium; tetrabutyl ammonium fluoride; silica gel; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340107