(2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Base Information

Chemical Name:(2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine
CAS No.:1632122-25-8
Molecular Formula:C₂₃H₂₇NO₃
Molecular Weight:365.472
Hs Code.:

Synonyms:(2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Suppliers and Price of (2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

There total 5 articles about (2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1632122-24-7
(2S,3aR,4R,6R,8aR,8bS)-4-(benzyloxymethyl)-6-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

: 1632122-25-8
(2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1055/s-0033-1340107

Reference yield:

: 1431853-29-0
(2S,3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

: 1632122-25-8
(2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydride; tert.-butylhydroperoxide; tetrabutyl ammonium fluoride / N,N-dimethyl-formamide

2: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

3: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran

4: silica gel / tetrahydrofuran

5: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 8 h / 80 °C

With tert.-butylhydroperoxide; n-butyllithium; tetrabutyl ammonium fluoride; silica gel; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340107

Reference yield:

: 1632122-20-3
C₁₅H₁₇NO₄

: 1632122-25-8
(2S,3aR,4R,6S,8aR,8bS)-4-(benzyloxymethyl)-6-methyl-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide

2: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran

3: silica gel / tetrahydrofuran

4: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 8 h / 80 °C

With n-butyllithium; tetrabutyl ammonium fluoride; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340107