2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester

Base Information

• Chemical Name: 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester
• CAS No.: 312305-53-6
• Molecular Formula: C₂₀H₂₈O₄
• Molecular Weight: 332.44
• Mol file: 312305-53-6.mol

Synonyms:2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester

Chemical Property of 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester

There total 6 articles about 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethene (74-85-1) + 2,4-dimethoxy-6-trifluoromethanesulfonyloxy-benzoic acid 1-methyl-oct-7-enyl ester (312305-52-5) → 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester (312305-53-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; lithium chloride; In N,N-dimethyl-formamide; at 90 ℃; for 20h; under 30003 Torr;

DOI:10.1021/jo0009999

Reference yield: 78.0%

tri-n-butyl(vinyl)tin (7486-35-3) + 2,4-dimethoxy-6-trifluoromethanesulfonyloxy-benzoic acid 1-methyl-oct-7-enyl ester (312305-52-5) → 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester (312305-53-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

DOI:10.1021/jo0009999

Reference yield:

(±)-8-nonen-2-ol (65727-63-1) → 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-oct-7-enyl ester (312305-53-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / PPh₃; DEAD / diethyl ether / 3 h / 20 °C

2: 92 percent / CH₂Cl₂; pyridine / 3 h / 0 °C

3: 92 percent / LiCl; Et₃N; PdCl₂(PPh₃)2 / dimethylformamide / 20 h / 90 °C / 30003 Torr

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate; In pyridine; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: trifluoromethylsulfonylation / 3: Heck reaction;

DOI:10.1021/jo0009999

upstream raw materials:

ethene

2,4-dimethoxy-6-trifluoromethanesulfonyloxy-benzoic acid 1-methyl-oct-7-enyl ester

tri-n-butyl(vinyl)tin

(±)-8-nonen-2-ol