ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

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Chemical Name:ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate
CAS No.:1366233-28-4
Molecular Formula:C₂₃H₂₃N₃O₃S
Molecular Weight:421.52
Hs Code.:

Synonyms:ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

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Chemical Property of ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

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Technology Process of ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

There total 3 articles about ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 693-98-1
2-methylimidazole

: 1366233-27-3
ethyl 3-(5-(4-bromothiophen-2-yl)-1-(4-hydroxyphenyl)-1H-pyrrol-2-yl)propanoate

: 1366233-28-4
ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 150 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.01.047

Reference yield:

: C₁₁H₇BrO₂S

: 1366233-28-4
ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / 8 h / Reflux

2: toluene-4-sulfonic acid / ethanol / Reflux

3: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 1 h / 150 °C / Microwave irradiation; Inert atmosphere

With copper(l) iodide; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; L-proline; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.01.047

Reference yield:

: 7209-11-2
2-acetyl-4-bromothiopene

: 1366233-28-4
ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 1 h / 20 °C

2: hydrogen bromide / 8 h / Reflux

3: toluene-4-sulfonic acid / ethanol / Reflux

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 1 h / 150 °C / Microwave irradiation; Inert atmosphere

With copper(l) iodide; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; L-proline; sodium hydroxide; In ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.01.047