3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

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Chemical Name:3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid
CAS No.:1208317-76-3
Molecular Formula:C₂₁H₁₉N₃O₃S
Molecular Weight:393.466
Hs Code.:

Synonyms:3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

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Chemical Property of 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

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Technology Process of 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

There total 6 articles about 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1366233-28-4
ethyl 3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoate

: 1208317-76-3
3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1016/j.bmcl.2012.01.047

Reference yield:

: C₁₁H₇BrO₂S

: 1208317-76-3
3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide / 8 h / Reflux

2: toluene-4-sulfonic acid / ethanol / Reflux

3: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 1 h / 150 °C / Microwave irradiation; Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; L-proline; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.01.047

Reference yield:

: 7209-11-2
2-acetyl-4-bromothiopene

: 1208317-76-3
3-(1-(4-hydroxyphenyl)-5-(4-(2-methyl-1H-imidazol-1-yl)thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol; water / 1 h / 20 °C

2: hydrogen bromide / 8 h / Reflux

3: toluene-4-sulfonic acid / ethanol / Reflux

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 1 h / 150 °C / Microwave irradiation; Inert atmosphere

5: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; L-proline; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.01.047