(R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Base Information

Chemical Name:(R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide
CAS No.:1353622-81-7
Molecular Formula:C₂₁H₂₅N₅O₄S
Molecular Weight:443.527
Hs Code.:

Synonyms:(R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Chemical Property of (R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Technology Process of (R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

There total 5 articles about (R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1353628-11-1
(R)-tert-butyl 2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate

: 162787-61-3
2-(methylsulfonamido)benzoic acid

: 1353622-81-7
(R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: (R)-tert-butyl 2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; methanol; for 1h;

2-(methylsulfonamido)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 16h;

for 16h;

Reference yield:

: 28697-17-8
N-BOC-D-pipecolic acid

: 1353622-81-7
(R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 16 h / Cooling with ice

2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -40 °C / Inert atmosphere

2.2: 1.5 h / -40 °C / Inert atmosphere

2.3: 0.5 h

3.1: hydrazine hydrate; acetic acid / ethanol / 18 h / 20 °C

4.1: acetic acid / ethanol / 5 h / Reflux

5.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

5.2: 16 h

5.3: 16 h

With hydrogenchloride; sodium bis(trimethylsilyl)amide; potassium carbonate; hydrazine hydrate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;

Reference yield:

: 1260609-63-9
(R)-tert-butyl 2-(2-cyanoacetyl)piperidine-1-carboxylate

: 1353622-81-7
(R)-N-(2-(2-(5,6-dimethyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate; acetic acid / ethanol / 18 h / 20 °C

2.1: acetic acid / ethanol / 5 h / Reflux

3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

3.2: 16 h

3.3: 16 h

With hydrogenchloride; hydrazine hydrate; acetic acid; In 1,4-dioxane; methanol; ethanol;