28697-17-8

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(+)-N-Boc-2-piperidinecarboxylic acid is used as a key intermediate for the development of various pharmaceuticals. Its chiral nature allows for the creation of enantiomerically pure compounds, which are essential in the synthesis of drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, (R)-(+)-N-Boc-2-piperidinecarboxylic acid is utilized as an intermediate for the synthesis of biologically active compounds, such as pesticides and herbicides. Its unique structure enables the development of more effective and targeted agrochemicals.
Used in Dye Industry:
(R)-(+)-N-Boc-2-piperidinecarboxylic acid is employed as an important intermediate in the synthesis of various dyes. Its versatile chemical properties allow for the creation of a wide range of colorants with different shades and properties.
Used as a Catalytic Agent:
(R)-(+)-N-Boc-2-piperidinecarboxylic acid is also applied as a catalytic agent in various chemical reactions. Its unique structure and reactivity make it a valuable component in the development of new and efficient catalytic processes.
Used as a Petrochemical Additive:
In the petrochemical industry, (R)-(+)-N-Boc-2-piperidinecarboxylic acid is used as an additive to enhance the performance of various products. Its incorporation can lead to improved properties such as increased stability, better flow characteristics, and enhanced resistance to degradation.

Upstream product

• 134441-61-5 tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 4043-87-2 pipecolic Acid 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 596129-26-9 (S)-1-(2,2,2-Trifluoro-acetyl)-piperidine-2-carboxylic acid (S)-3,4,4-trimethyl-2-oxo-tetrahydro-furan-3-yl ester 
• 124-38-9 carbon dioxide 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 1013212-42-4 tert-butyl 1-(R)-2-((S)-1,2-dihydroxylethyl)piperidine-1-carboxylate 
• 164456-75-1 1-(R)-tert-butyl 2-methyl piperidine-1,2-dicarboxylate 
• 18650-38-9 (R)-piperidine-2-carboxylic acid methyl ester hydrochloride 
• 116696-85-6 (2S)-2-t-butoxycarbonylamino-3-phenylsulfonyl-1-(2-tetrahydropyranyloxy)propane 
• 170642-32-7 (S,S)-pseudoephedrine D-pipecolinamide 
• 596129-25-8 (+/-)-N-trifluoroacetyl pipecolic acid 

Downstream Products

• 936025-56-8 2-{4-[4-(2,4-dichloro-benzylamino)-pyrido[2,3-d]pyrimidin-2-yl]-piperazine-1-carbonyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 203056-20-6 (2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone 
• 203056-24-0 (2R)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-methoxyphenyl ketone 
• 164456-75-1 1-(R)-tert-butyl 2-methyl piperidine-1,2-dicarboxylate 
• 942207-21-8 phenylmethyl 4-[((2R)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-2-piperidinyl)carbonyl]-1-piperazinecarboxylate 
• 1030274-06-6 C₃₄H₄₅N₅O₉ 
• 1100736-48-8 14-O-[(3-{[((R)-tert-butoxycarbonylpiperidine-2-carbonyl)-amino]-methyl}-phenylsulfanyl)-acetyl]-mutilin 
• 1030274-06-6 MeO-Arg(di-Z)-D-Pip-Boc 
• 561038-60-6 (R)-2-benzyl 1-tert-butyl piperidine-1,2-dicarboxylate 
• 688809-99-6 (R)-2-methoxymethylpiperidine hydrochloride 
• 134441-61-5 tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 1472657-33-2 (R)-1-(3-bromo-2-methylphenylsulfonyl)-N-cycloheptylpiperidine-2-carboxamide 

Relevant academic research and scientific papers

MEDICINE CONTAINING ANTIBODY DRUG CONJUGATE CONTAINING HEMIASTERLIN DERIVATIVE

PROBLEM TO BE SOLVED: To provide medicines containing an antibody drug conjugate containing a hemiasterlin derivative, in which specific cytotoxicity to target cells is given, while cytotoxicity to normal cells is suppressed. SOLUTION: Provided is a medicine represented by formula (2-1), and containing an antibody drug conjugate or a pharmaceutically acceptable salt thereof [where, mAb represents an antibody, q represents an integer from 1 to 8, b represents an integer from 1 to 5, Z is a group represented by formula (Z-1), formula (Z-2), formula (Z-3), formula (Za-1), formula (Za-2), formula (Za-3), formula (Za-4), or formula (Za-5)]. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

MORPHINAN DERIVATIVE

A compound represented by the following general formula (I), wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms and the alkylene moiety has 1 to 5 carbon atoms, or the like, R2 represents a 4- to 7-membered saturated heterocycle containing one or two heteroatoms which may be the same or different and are selected from N, O, and S, and two or more carbon atoms as ring-constituting atoms, the heterocycle may be substituted with a substituent such as an oxo group, R2 binds to Y via a carbon atom as a ring-constituting atom of R2, R3, R4, and R5, which are the same or different, represent hydrogen; hydroxy; or the like, R6a and R6b, which are the same or different, represent hydrogen or the like, R7 and R8, which are the same or different, represent hydrogen or the like, R9 and R10, which are the same or different, represent hydrogen or the like, X represents O or CH2, and Y represents C(= O) or the like), a tautomer of the compound, a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic, an antidepressant, or the like.

Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs

(-)-Cryptopleurine 1 is one of the most potent anti-proliferative member of the phenanthroquinolizidine class of alkaloids. We report here the synthesis of (-)-6-O-desmethylcryptopleurine (-)-2 and (-)-6-O-desmethyl-(15R)-hydroxycryptopleurine (-)-4 in th

PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF

Provided are piperazinyl pyrimidine derivatives of formula I having CCR4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and preve

PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF

Provided are piperazinyl pyrimidine derivatives of formula I having CCR4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and preve

SWEET FLAVOR MODIFIER

The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of modulating the sweet taste of compositions.

Design and Synthesis of (R)-1-Arylsulfonylpiperidine-2-carboxamides as 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors

R adamantly beats S: 11β-HSD1 is a target for treating metabolic syndrome. The Risomer 5 was selected as a starting point for optimization and SAR studies. Inhibitor 8w emerged after several rounds of optimization, showing cross-species inhibition of human and mouse 11β-HSD1. It also displays a good DMPK profile invitro, and was advanced to PK/PD evaluations invivo. The results confirmed its dose-dependent activity in mice.

Organocatalytic one-pot oxidative cleavage of terminal diols to dehomologated carboxylic acids

The organocatalytic one-pot oxidative cleavage of terminal 1,2-diols to one-carbon-unit-shorter carboxylic acids is described. The combination of 1-Me-AZADO (cat.), NaOCl (cat.), and NaClO2 caused smooth one-pot oxidative cleavage under mild conditions. A broad range of substrates including carbohydrates and N-protected amino diols were converted without epimerization. Terminal triols and tetraols respectively underwent cleavage of their C-2 and C-3 moieties to afford their corresponding two- and three-carbon-unit-shorter carboxylic acids.

Nitroxyl radical/PhI(OAc)2: One-pot oxidative cleavage of vicinal diols to (di)carboxylic acids

A mild and user-friendly one-pot oxidative cleavage of vicinal diols to their corresponding (di)carboxylic acids using AZADOs and PhI(OAc)2 is described. 1,2-Diols and 2,3-diols as well as 1,2,3-triol gave one- or two-carbon-unit-shorter carboxylic acids. Internal vicinal diols also smoothly underwent one-pot oxidative cleavage to afford the corresponding dicarboxylic acids. Cyclic vicinal diols are converted to their corresponding open-form dicarboxylic acids.

PHARMACEUTICALLY ACTIVE DISUBSTITUTED TRIAZINE DERIVATIVES

The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.