N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Base Information

Chemical Name:N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide
CAS No.:1450923-75-7
Molecular Formula:C₂₈H₂₄F₃N₃O₄S₂
Molecular Weight:587.643
Hs Code.:

Synonyms:N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Chemical Property of N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Technology Process of N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

There total 3 articles about N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450923-46-2
4-(2-bromo-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

: 75927-49-0
pinacol vinylboronate

: 1450923-75-7
N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; Sealed tube;

Reference yield:

: 1450923-24-6
N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

: 1450923-75-7
N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 100 °C / Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; water; toluene;

Reference yield:

: 481075-58-5
2-bromo-1-iodo-4-(trifluoromethyl)benzene

: 1450923-75-7
N-(4-methoxybenzyl)-N-(thiazol-2-yl)-4-(4-(trifluoromethyl)-2-vinylphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 100 °C / Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; water; toluene;