3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide

Base Information

• Chemical Name: 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide
• CAS No.: 1201663-68-4
• Molecular Formula: C₂₈H₂₄Cl₂F₂N₂O₃S
• Molecular Weight: 577.479
• Mol file: 1201663-68-4.mol

Synonyms:3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide

Chemical Property of 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide

There total 5 articles about 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-(4-(aminomethyl)benzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide (1201663-67-3) + 4-fluorobenzaldehyde (459-57-4) → 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide (1201663-68-4)

Guidance literature:

N-(4-(aminomethyl)benzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide; 4-fluorobenzaldehyde; In dichloromethane; isopropyl alcohol; at 20 ℃;

With sodium tetrahydroborate; In dichloromethane; isopropyl alcohol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

tert-butyl 4-(aminomethyl)benzylcarbamate (108468-00-4) → 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide (1201663-68-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dichloromethane; isopropyl alcohol / 20 °C

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: dichloromethane; isopropyl alcohol / 20 °C

4.2: 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;

Reference yield:

tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate (1201663-65-1) → 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide (1201663-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: dichloromethane; isopropyl alcohol / 20 °C

3.2: 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;

upstream raw materials:

N-(4-(aminomethyl)benzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

4-fluorobenzaldehyde

tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate

3,5-dichloro-2-hydroxybenzenesulfonyl chloride

Downstream raw materials:

3,5-dichloro-N-(4-((3,5-dichloro-N-(4-fluorobenzyl)phenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

N-(4-((3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-6-(trifluoromethyl)pyridine-3-sulfonamide