tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate

Base Information

• Chemical Name: tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate
• CAS No.: 1201663-65-1
• Molecular Formula: C₂₀H₂₅FN₂O₂
• Molecular Weight: 344.429
• Mol file: 1201663-65-1.mol

Synonyms:tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate

Chemical Property of tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate

There total 1 articles about tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

sodium tetrahydroborate (16940-66-2) + 4-fluorobenzaldehyde (459-57-4) + tert-butyl 4-(aminomethyl)benzylcarbamate (108468-00-4) → tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate (1201663-65-1)

Guidance literature:

4-fluorobenzaldehyde; tert-butyl 4-(aminomethyl)benzylcarbamate; In dichloromethane; isopropyl alcohol; at 20 ℃;

sodium tetrahydroborate; In dichloromethane; isopropyl alcohol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; dichloromethane; water; isopropyl alcohol;

Reference yield: 53.0%

tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate (1201663-65-1) + 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (23378-88-3) → tert-butyl 4-((3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate (1201663-66-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate (1201663-65-1) → 3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide (1201663-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: dichloromethane; isopropyl alcohol / 20 °C

3.2: 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;

upstream raw materials:

sodium tetrahydroborate

4-fluorobenzaldehyde

tert-butyl 4-(aminomethyl)benzylcarbamate

Downstream raw materials:

tert-butyl 4-((3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

N-(4-(aminomethyl)benzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

3,5-dichloro-N-(4-fluorobenzyl)-N-(4-((4-fluorobenzylamino)methyl)benzyl)-2-hydroxybenzenesulfonamide

3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide