8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester

Base Information

Chemical Name:8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester
CAS No.:1027532-36-0
Molecular Formula:C₂₂H₃₂N₄O₄
Molecular Weight:416.52
Hs Code.:

Synonyms:8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester

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Chemical Property of 8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester

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Technology Process of 8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester

There total 2 articles about 8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29823-21-0
Ethyl 8-bromooctanoate

: 397245-73-7
2,4-diamino-5-(2-methoxy-5-hydroxybenzyl)pyrimidine

: 1027532-36-0
8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester

Guidance literature:: 2,4-diamino-5-(2-methoxy-5-hydroxybenzyl)pyrimidine; With sodium ethanolate; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

Ethyl 8-bromooctanoate; In dimethyl sulfoxide; at 20 ℃; for 2h; Further stages.;
DOI:10.1021/jm010407u

Reference yield:

: 22159-41-7
methyl 4-methoxyphenyl carbonate

: 1027532-36-0
8-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenoxy]-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: TiCl₄ / CH₂Cl₂ / 0.5 h / 20 °C

2.1: 23 g / 12 N aq. HCl / ethyl acetate / 0.5 h / 0 °C

3.1: NaOMe / methanol / 0.08 h / 20 °C

4.1: 1.91 g / dimethylformamide / 20 h / 20 °C

5.1: NaOMe / dimethylsulfoxide / 0.33 h / 100 °C

6.1: ethanol / 1 h / Heating

7.1: NaOEt / ethanol / 0.08 h

7.2: 61 percent / ethanol / 20 h / Heating

8.1: 89 percent / TsOH*H₂O / methanol / 48 h / 20 °C

9.1: NaOEt / dimethylsulfoxide / 0.5 h / 20 °C

9.2: dimethylsulfoxide / 2 h / 20 °C

With hydrogenchloride; sodium methylate; sodium ethanolate; titanium tetrachloride; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010407u