N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide

Base Information

Chemical Name:N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide
CAS No.:1580443-52-2
Molecular Formula:C₄₀H₅₈N₆O₉
Molecular Weight:766.935
Hs Code.:

Synonyms:N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide

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Chemical Property of N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide

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Technology Process of N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide

There total 3 articles about N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 957486-82-7
O-(2-aminoethyl)-O′-(2-azidoethyl)pentaethylene glycol

: 1580443-51-1
C₂₈H₃₄N₂O₄

: 1580443-52-2
N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide

Guidance literature:: C₂₈H₃₄N₂O₄; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.25h;

O-(2-aminoethyl)-O′-(2-azidoethyl)pentaethylene glycol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.ejmech.2013.12.020

Reference yield:

: 7182-29-8
5-hydroxy-2-phenylbenzofuran

: 1580443-52-2
N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; water / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C

2.2: 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; 1.1: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.12.020

Reference yield:

: 344779-08-4
ethyl (1,4'-bipiperidine)-4-carboxylate

: 1580443-52-2
N-(20-azido-3,6,9,12,15,18-hexaoxaicosyl)-1'-((5-hydroxy-2-phenylbenzofuran-4-yl)methyl)(1,4'-bipiperidine)-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; water / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C

2.2: 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; 1.1: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.12.020