(4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate

Base Information

Chemical Name:(4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate
CAS No.:1190308-63-4
Molecular Formula:C₃₁H₂₉N₃O₈
Molecular Weight:571.587
Hs Code.:

Synonyms:(4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate

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Chemical Property of (4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate

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Technology Process of (4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate

There total 2 articles about (4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 6829-40-9
aminomalonic acid diethyl ester

: 22144-87-2
(E)-1-acetyl-2,3-dihydro-3-(2-phenylmethylene)-2H-indol-2-one

: 99-61-6
3-nitro-benzaldehyde

: 1190308-63-4
(4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate

Guidance literature:: With (R)-2,6-bis(naphthalen-2-yl)-4-oxo-3,5-dioxa-4λ⁵-phosphacyclohepta[2,1-a;3,4-a']dinapthalen-4-ol; In dichloromethane; at 25 ℃; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja905302f

Reference yield: 96.0%

: C₁₇H₁₄N₂O₃

: 100-46-9
benzylamine

: 609-09-6
Diethyl ketomalonate

: 1190308-63-4
(4'S,5'S)-diethyl 1-acetyl-5'-(3-nitrophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-2',2'-dicarboxylate

Guidance literature:: benzylamine; Diethyl ketomalonate; With (R)-2,6-bis(naphthalen-2-yl)-4-oxo-3,5-dioxa-4λ⁵-phosphacyclohepta[2,1-a;3,4-a']dinapthalen-4-ol; In dichloromethane; at 25 ℃; for 4h; Molecular sieve;

C₁₇H₁₄N₂O₃; In dichloromethane; at 50 ℃; enantioselective reaction; Molecular sieve;
DOI:10.1021/ol400983j