5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione

Base Information

• Chemical Name: 5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione
• CAS No.: 1608154-37-5
• Molecular Formula: C₁₃H₁₃FN₂O₃
• Molecular Weight: 264.256
• Mol file: 1608154-37-5.mol

Synonyms:5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione

Chemical Property of 5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione

There total 3 articles about 5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

oxiranyl-methanol (556-52-5) + 5-(4-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione (428-22-8,6270-38-8) → 5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione (1608154-37-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 90.75h;

DOI:10.1016/j.ejmech.2014.01.065

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione (1608154-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium carbonate / ethanol / 55 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 90.75 h / 0 - 20 °C

With ammonium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; 1: |Bucherer-Bergs Reaction / 2: |Mitsunobu Displacement;

DOI:10.1016/j.ejmech.2014.01.065

Reference yield:

epichlorohydrin (106-89-8,24969-06-0,13403-37-7) + 5-(4-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione (428-22-8,6270-38-8) → 5-(4-fluorophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione (1608154-37-5)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 10h;

DOI:10.1039/c8md00168e

upstream raw materials:

1-(4-fluorophenyl)ethanone

oxiranyl-methanol

5-(4-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione

epichlorohydrin

Downstream raw materials:

5-(4-fluorophenyl)-3-(3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-hydroxypropyl)-5-methylimidazolidine-2,4-dione