Technology Process of 4-methyl-8-[2-(phenylsulfonyl)ethyl]-1,2,3,5,10,10a-hexahydropyrrolidino[3,2-b]indol-4-ium
There total 5 articles about 4-methyl-8-[2-(phenylsulfonyl)ethyl]-1,2,3,5,10,10a-hexahydropyrrolidino[3,2-b]indol-4-ium which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide;
In
water; acetonitrile;
at 80 - 85 ℃;
for 0.75h;
DOI:10.3762/bjoc.8.162
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / N,N-dimethyl-formamide / 4.17 h / 90 - 100 °C
2: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 100 °C
3: potassium carbonate / acetonitrile; water / 5 - 10 °C
4: 10% Pd/C; hydrogen bromide / water; acetone / 25 - 30 °C
5: dihydrogen peroxide / acetonitrile; water / 0.75 h / 80 - 85 °C
With
10% Pd/C; hydrogen bromide; dihydrogen peroxide; palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine;
In
water; N,N-dimethyl-formamide; acetone; acetonitrile;
2: |Heck Reaction;
DOI:10.3762/bjoc.8.162
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 100 °C
2: potassium carbonate / acetonitrile; water / 5 - 10 °C
3: 10% Pd/C; hydrogen bromide / water; acetone / 25 - 30 °C
4: dihydrogen peroxide / acetonitrile; water / 0.75 h / 80 - 85 °C
With
10% Pd/C; hydrogen bromide; dihydrogen peroxide; palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine;
In
water; N,N-dimethyl-formamide; acetone; acetonitrile;
1: |Heck Reaction;
DOI:10.3762/bjoc.8.162
