(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

Base Information

• Chemical Name: (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
• CAS No.: 180637-88-1
• Molecular Formula: C₂₄H₂₆N₂O₃S
• Molecular Weight: 422.548
• Mol file: 180637-88-1.mol

Synonyms:(R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

Chemical Property of (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

There total 10 articles about (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

PVS (5535-48-8) + (R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole (143322-57-0,208464-41-9,312949-16-9) → (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole (180637-88-1)

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; for 7.5h; Heating / reflux; Industry scale;

Reference yield: 69.0%

(R)-1-acetyl-5-bromo-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole (205369-12-6) + PVS (5535-48-8) → (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole (180637-88-1)

Guidance literature:

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 25 - 120 ℃; for 0.25h;

DOI:10.1021/op3002454

Reference yield:

PVS (5535-48-8) + acetic anhydride (108-24-7) + (R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole (143322-57-0,208464-41-9,312949-16-9) → (R)-1-acetyl-5-[2-(phenylsulfonyl)ethyenyl]-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole (180637-88-1) + methylphenylsulfonate (3112-85-4)

Guidance literature:

acetic anhydride; (R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole; With triethylamine; In acetonitrile; for 4.5h; Reflux;

PVS; With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; for 7.5h; Reflux;

upstream raw materials:

PVS

(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

acetic anhydride

5-bromo-3-(1-methylpyrrolidin-2(R)-ylmethyl)-1H-indole

Downstream raw materials:

(R)-5-[(2-phenylsulfonyl)ethenyl]-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

(R)-1-acetyl-5-(2-benzenesulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole

(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole formate

(R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidine-2-yl-methyl)-1H-indole methanesulphonate