3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide

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Chemical Name:3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide
CAS No.:1334764-15-6
Molecular Formula:C₂₈H₂₅N₇O₂
Molecular Weight:491.552
Hs Code.:

Synonyms:3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide

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Chemical Property of 3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide

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Technology Process of 3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide

There total 6 articles about 3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1334764-11-2
N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]ethanethioamide

: 1334764-15-6
3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In ethanol; at 40 ℃; for 4h;
DOI:10.1016/j.ejmech.2011.05.063

Reference yield:

: 614750-85-5
diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate

: 1334764-15-6
3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 16 h / 20 °C

1.2: 1 h

1.3: pH 7 - 8

2.1: acetic acid / N,N-dimethyl-formamide / 2 h / 80 °C

2.2: 4 h / Reflux

3.1: sodium hydride; sodium iodide / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C

5.1: dihydrogen peroxide; sodium hydroxide / ethanol / 4 h / 40 °C

With Lawessons reagent; dihydrogen peroxide; sodium hydride; caesium carbonate; acetic acid; sodium iodide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.05.063

Reference yield:

: 108763-28-6
2,3-dimethylquinoxaline-6-carbaldehyde

: 1334764-15-6
3-{2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamido}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 16 h / 20 °C

1.2: 1 h

1.3: pH 7 - 8

2.1: acetic acid / N,N-dimethyl-formamide / 2 h / 80 °C

2.2: 4 h / Reflux

3.1: sodium hydride; sodium iodide / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C

5.1: dihydrogen peroxide; sodium hydroxide / ethanol / 4 h / 40 °C

With Lawessons reagent; dihydrogen peroxide; sodium hydride; caesium carbonate; acetic acid; sodium iodide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.05.063