5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Chemical Name:5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine
CAS No.:1453207-55-0
Molecular Formula:C₃₁H₄₂N₆O₃
Molecular Weight:546.713
Hs Code.:

Synonyms:5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Chemical Property of 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

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Technology Process of 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

There total 3 articles about 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1453207-54-9
5-[(3,5-dimethoxyphenyl)ethynyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

: 1453207-55-0
5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 5h; under 2280.15 Torr;
DOI:10.1016/j.bmc.2021.116019

Reference yield:

: 1453211-46-5
5-bromo-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

: 1453207-55-0
5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 2.5 h / 120 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 4 h / 2280.15 Torr / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1254058-34-8
3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

: 1453207-55-0
5-[2-(3,5-dimethoxyphenyl)ethyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonic acid / ethanol / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h / 100 °C

2.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 2.5 h / 120 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 4 h / 2280.15 Torr / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;