3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

Base Information

• Chemical Name: 3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline
• CAS No.: 1254058-34-8
• Molecular Formula: C17H28N4O
• Molecular Weight: 304.436
• Mol file: 1254058-34-8.mol

Synonyms:3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline;3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]benzenamine;Benzenamine, 3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-;3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperi...

Chemical Property of 3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

Chemical Property:

• PSA: 44.97000
• LogP: 2.01560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

There total 3 articles about 3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

1-[1-(2-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine (1254058-33-7) → 3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1254058-34-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

1-fluoro-2-methoxy-4-nitrobenzene (454-16-0) → 3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1254058-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c17-00784

Reference yield:

1-methyl-4-(piperidin-4-yl)piperazine (53617-36-0) → 3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1254058-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / ethanol; tetrahydrofuran / 8 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c17-00784

upstream raw materials:

1-fluoro-2-methoxy-4-nitrobenzene

1-[1-(2-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine

1-methyl-4-(piperidin-4-yl)piperazine

Downstream raw materials:

5-[(3,5-dimethoxyphenyl)methoxy]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

5-[(3,5-dimethoxyphenoxy)methyl]-N-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Refernces

• 1、 -. "SUBSTITUTED DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND AND A COMPOSITION CONTAINING THE COMPOUND AND USE THEREOF". . . Retrieved 2020/12/07.