methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate

Base Information

• Chemical Name: methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate
• CAS No.: 1377934-40-1
• Molecular Formula: C₁₁H₁₀F₄O₅S
• Molecular Weight: 330.257
• Mol file: 1377934-40-1.mol

Synonyms:methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate

Chemical Property of methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate

There total 5 articles about methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trifluoromethylsulfonic anhydride (358-23-6) + methyl 2-(2-fluoro-4-hydroxyphenyl)propanoate (1204310-44-0) → methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate (1377934-40-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1021/jm300049g

Reference yield:

2-(2-fluoro-4-nitrophenyl)propanoic acid (111196-84-0) → methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate (1377934-40-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / water / 3 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / 12 h / 20 °C / 760.05 Torr

3.1: sulfuric acid; water; sodium nitrite / 0 - 5 °C

3.2: 2 h / Reflux

4.1: hydrogenchloride / water / 3 h / Reflux

5.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; triethylamine; sodium nitrite; In dichloromethane; water;

DOI:10.1021/jm300049g

Reference yield:

C9H9FO3 → methyl 2-[2-fluoro-4-(trifluoromethylsulfonyloxy)phenyl]propanoate (1377934-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 3 h / Reflux

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; water;

DOI:10.1021/jm300049g

upstream raw materials:

2-(2-fluoro-4-nitrophenyl)propanoic acid

methyl 2-(4-amino-2-fluorophenyl)propanoate

trifluoromethylsulfonic anhydride

methyl 2-(2-fluoro-4-hydroxyphenyl)propanoate

Downstream raw materials:

methyl 2-(2-fluoro-4-methylphenyl)propanoate

2-[2-fluoro-4-(2-methyl-3-oxopentyl)phenyl]propanoic acid

2-[4-(2-ethyl-3-oxobutyl)-2-fluorophenyl]propanoic acid

2-[2-fluoro-4-(thiophene-3-ylmethyl)phenyl]propionic acid