9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine

Base Information

Chemical Name:9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine
CAS No.:214153-97-6
Molecular Formula:C₃₁H₃₀FN₅O₃S
Molecular Weight:571.675
Hs Code.:

Synonyms:9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine

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Chemical Property of 9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine

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Technology Process of 9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine

There total 5 articles about 9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 214153-96-5
9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-9H-purine-2,6-diamine

: 214153-97-6
9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine

Guidance literature:: With pyridine; tert.-butylnitrite; hydrogen fluoride; at -20 - -15 ℃; for 3.75h;
DOI:10.1021/jm980195+

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 214153-97-6
9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / SnCl₄ / acetonitrile / 2 h / Ambient temperature

2: 290 mg / NaN₃ / ethanol / 2 h / Heating

3: SnCl₂, MeOH / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 76 percent / tert-butyl nitrite, HF, pyridine / 3.75 h / -20 - -15 °C

With pyridine; methanol; sodium azide; tert.-butylnitrite; hydrogen fluoride; tin(IV) chloride; tin(ll) chloride; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm980195+

Reference yield:

: 169736-20-3
1-O-acetyl-2,3,5-tri-O-benzyl-4-thio-D-arabinofuranose

: 214153-97-6
9-((2R,3S,4S,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-2-fluoro-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / SnCl₄ / acetonitrile / 2 h / Ambient temperature

2: 290 mg / NaN₃ / ethanol / 2 h / Heating

3: SnCl₂, MeOH / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 76 percent / tert-butyl nitrite, HF, pyridine / 3.75 h / -20 - -15 °C

With pyridine; methanol; sodium azide; tert.-butylnitrite; hydrogen fluoride; tin(IV) chloride; tin(ll) chloride; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm980195+