6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole

Base Information

• Chemical Name: 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole
• CAS No.: 1245464-62-3
• Molecular Formula: C₁₆H₁₀BrClN₄O₃S
• Molecular Weight: 453.703

Synonyms:6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole

Chemical Property of 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole

There total 3 articles about 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

6-bromo-1-(phenylsulfonyl)-4-(1H-tetrazol-5-yl)-1H-indazole (1245464-59-8) + chloroacetyl chloride (79-04-9) → 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole (1245464-62-3)

Guidance literature:

In chloroform; at 60 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01556

Reference yield:

6-bromo-1-(phenylsulfonyl)-1H-indazole-4-carbonitrile (1245464-68-9) → 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole (1245464-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 4 h / 110 °C / Inert atmosphere

2: chloroform / 60 °C / Inert atmosphere

With trimethylsilylazide; di(n-butyl)tin oxide; In chloroform; toluene;

DOI:10.1021/acs.jmedchem.8b01556

Reference yield:

→ 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole (1245464-62-3)

Guidance literature:

In toluene; at 130 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

6-bromo-1-(phenylsulfonyl)-1H-indazole-4-carbonitrile

6-bromo-1-(phenylsulfonyl)-4-(1H-tetrazol-5-yl)-1H-indazole

chloroacetyl chloride

Downstream raw materials:

1-[({5-[6-bromo-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3,4-oxadiazol-2-yl}methyl)amino]-3-(4-morpholinyl)-2-propanol

6-bromo-4-{5-[(8aS)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylmethyl]-1,3,4-oxadiazol-2-yl}-1-(phenylsulfonyl)-1H-indazole

6-bromo-4-{5-[(2,2-dimethyl-4-morpholinyl)methyl]-1,3,4-oxadiazol-2-yl}-1-(phenylsulfonyl)-1H-indazole

6-bromo-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3,4-oxadiazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1245464-62-3 6-bromo-4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-1-(phenylsulfonyl)-1H-indazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send