(3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide

Base Information

Chemical Name:(3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide
CAS No.:180600-04-8
Molecular Formula:C₃₄H₃₇N₂O₅P
Molecular Weight:584.652
Hs Code.:

Synonyms:(3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide

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Chemical Property of (3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide

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Technology Process of (3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide

There total 4 articles about (3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 167827-90-9
5,6-Dihydroxy-(4α,5α,6β,7β)-hexahydro-1,3-bis(4-(hydroxymethyl)phenylmethyl)-2-phenoxy-4,7-bis(phenyl-methyl)-1H-1,3,2-diazaphosphepine 2-oxide

: 180600-04-8
(3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; for 1h; Ambient temperature;
DOI:10.3987/com-96-7524

Reference yield:

: 153223-10-0
(2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol

: 180600-04-8
(3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / camphor sulfonic acid / CH₂Cl₂ / 48 h / Ambient temperature

2: 100 percent / hydrogen / 10percent Pd/C / tetrahydrofuran; ethanol / 18 h / 760 Torr

3: 64 percent / triethylamine / tetrahydrofuran / 16 h / Ambient temperature

4: 71 percent / sodium hydride, tetrabutylammonium iodide / dimethylformamide / 36 h / Ambient temperature

5: 44 percent / p-toluenesulfonic acid monohydrate / methanol / 1 h / Ambient temperature

6: 77 percent / lithium hydroxyde / tetrahydrofuran; H₂O / 1 h / Ambient temperature

With lithium hydroxide; camphor-10-sulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7524

Reference yield:

: 177574-46-8
dibenzyl ((1R,1'R)-((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate

: 180600-04-8
(3-endo,4-endo,6-exo)-2,7-bis(4-(hydroxymethyl)benzyl)-3,6-bisbenzyl-8-oxa-2,7-diaza-1-phosphabicyclo[3.2.1]octan-4-ol-1-oxide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / hydrogen / 10percent Pd/C / tetrahydrofuran; ethanol / 18 h / 760 Torr

2: 64 percent / triethylamine / tetrahydrofuran / 16 h / Ambient temperature

3: 71 percent / sodium hydride, tetrabutylammonium iodide / dimethylformamide / 36 h / Ambient temperature

4: 44 percent / p-toluenesulfonic acid monohydrate / methanol / 1 h / Ambient temperature

5: 77 percent / lithium hydroxyde / tetrahydrofuran; H₂O / 1 h / Ambient temperature

With lithium hydroxide; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7524