(E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate

Base Information

Chemical Name:(E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate
CAS No.:951214-06-5
Molecular Formula:C₂₂H₂₈NO₅P
Molecular Weight:417.442
Hs Code.:

Synonyms:(E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate

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Chemical Property of (E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate

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Technology Process of (E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate

There total 11 articles about (E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951213-55-1
C₇H₁₃PO₃Br₂

: 951214-06-5
(E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: NaI / acetone / 20 °C

2: NaH / dimethylformamide / 20 °C

3: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 80 °C

4: TFA / CH₂Cl₂ / 0 °C

5: pyridine / 20 °C

With sodium hydride; sodium carbonate; trifluoroacetic acid; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetone; 1: Finkelstein reaction / 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.06.026

Reference yield:

: 951213-61-9
C₇H₁₃PO₃BrI

: 951214-06-5
(E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 20 °C

2: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 80 °C

3: TFA / CH₂Cl₂ / 0 °C

4: pyridine / 20 °C

With sodium hydride; sodium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.06.026

Reference yield:

: 951213-75-5
C₁₉H₂₉NO₆BrP

: 951214-06-5
(E)-diethyl (3-(N-(benzyloxy)acetamido)-1-phenylprop-1-en-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 80 °C

2: TFA / CH₂Cl₂ / 0 °C

3: pyridine / 20 °C

With sodium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; 1,2-dimethoxyethane; dichloromethane; water; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.06.026