(2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile

Base Information

Chemical Name:(2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile
CAS No.:318471-81-7
Molecular Formula:C₁₄H₂₀N₂OS
Molecular Weight:264.392
Hs Code.:

Synonyms:(2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile

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Chemical Property of (2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile

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Technology Process of (2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile

There total 3 articles about (2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5804-85-3
diethylaluminium cyanide

: 67-63-0,8013-70-5
isopropyl alcohol

: 318471-70-4
(S)-(+)-N-(1,2,2-trimethylpropylidene)-p-toluenesulfinamide

: 318471-81-7
(2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile

Guidance literature:: diethylaluminium cyanide; isopropyl alcohol; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;

(S)-(+)-N-(1,2,2-trimethylpropylidene)-p-toluenesulfinamide; In tetrahydrofuran; at -78 - 20 ℃; for 15h; Further stages.;
DOI:10.1021/jo001179z

Reference yield:

: 75-97-8
3,3-dimethyl-butan-2-one

: 318471-81-7
(2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 42 percent / Ti(OEt)4 / CH₂Cl₂ / 18 h / Heating

2.1: tetrahydrofuran / 0.5 h / -78 - 20 °C

2.2: 95 percent / tetrahydrofuran / 15 h / -78 - 20 °C

With titanium(IV) tetraethanolate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo001179z

Reference yield:

: 188447-91-8
(S)-p-toluenesulfinimide

: 318471-81-7
(2S)-(+)-[(S)-N-p-toluenesulfinyl]-2-amino-2,3,3-trimethylbutyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 42 percent / Ti(OEt)4 / CH₂Cl₂ / 18 h / Heating

2.1: tetrahydrofuran / 0.5 h / -78 - 20 °C

2.2: 95 percent / tetrahydrofuran / 15 h / -78 - 20 °C

With titanium(IV) tetraethanolate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo001179z