1-HYDROXYPHENAZINE

Base Information

• Chemical Name: 1-HYDROXYPHENAZINE
• CAS No.: 528-71-2
• Molecular Formula: C12H8 N2 O
• Molecular Weight: 196.208
• Hs Code.: 2933990090
• Mol file: 528-71-2.mol

Synonyms:Hemipyocyanine(6CI); 1-Hydroxy-9,10-diazaanthracene; 1-Hydroxyphenazine; Hemipyocyanin; NSC88882; Pyoxanthose; a-Hydroxyphenazine

Chemical Property of 1-HYDROXYPHENAZINE

Chemical Property:

• Melting Point: 158°C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 333.09°C (rough estimate)
• PKA: 6.62±0.30(Predicted)
• Flash Point: 213.864oC
• PSA: 46.01000
• Density: 1.1788 (rough estimate)
• LogP: 2.48860

Purity/Quality:

98% ^*data from raw suppliers

Hemipyocyanine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hemipyocyanine (1-hydroxyphenazine) is a simple phenazine metabolite produced by several species of Pseudomonas and Streptomyces. Hemipyocyanine exhibits broad spectrum activity with weak antibacterial, antifungal and antiviral activity. In the search for novel actives, hemipyocyanine and related phenazines are important dereplication standards to eliminate leads due to high amounts of weakly potent actives. Hemipyocyanine plays an important role in the biocontrol of plant diseases by some Pseudomonas strains. Hemipyocyanine is a phenazine metabolite and important dereplication standard.

Technology Process of 1-HYDROXYPHENAZINE

There total 34 articles about 1-HYDROXYPHENAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phenazine methosulfate (299-11-6) → phenazin-1-ol (528-71-2)

Guidance literature:

With water; Flow reactor;

DOI:10.1002/ejoc.201900526

Reference yield: 80.0%

1-methoxyphenazine (2876-17-7) → phenazin-1-ol (528-71-2)

Guidance literature:

With hydrogen bromide; In water; at 120 ℃; for 5h;

DOI:10.1080/10286020.2021.1982909

Reference yield: 37.0%

2-{[2-(phenyldiazenyl)phenyl]amino}phenol → phenazin-1-ol (528-71-2)

Guidance literature:

With trifluoroacetic acid; at 20 ℃;

DOI:10.1016/j.tetlet.2020.152511

upstream raw materials:

Phenazin

phenazin-1-ylamine

1-chlorophenazine

1-methoxyphenazine

Downstream raw materials:

1-methoxyphenazine

phenazin-1-yl acetate

1-hydroxyphenazine 5,10-dioxide

1-hydroxyphenazine N′ 10-oxide

Refernces

• 1、 Bao, Xiao-Feng,Jiang, He,Liu, Zi-Yi,Xie, Wen-Xia,Zhao, Yu,Zhu, Li,Zhu, Yi-Xin. "Synthesis of 1-substituted phenazines as novel antichlamydial agents". . . Retrieved 2021/10/21.
• 2、 -. "BIOMARKER PANEL TARGETED TO DISEASES DUE TO MULTIFACTORIAL ONTOLOGY OF GLYCOCALYX DISRUPTION". Paragraph 0291; 0305. . Retrieved 2021/04/02.