Name: 1-HYDROXYPHENAZINE
SKU: 528-71-2

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Basic Information

Molecular Structure:
CAS No.:	528-71-2
Name:	1-HYDROXYPHENAZINE

Formula:	C12H8 N2 O
Molecular Weight:	196.208
Synonyms:	Hemipyocyanine(6CI); 1-Hydroxy-9,10-diazaanthracene; 1-Hydroxyphenazine; Hemipyocyanin; NSC88882; Pyoxanthose; a-Hydroxyphenazine
Density:	1.1788 (rough estimate)
Melting Point:	158°C
Boiling Point:	333.09°C (rough estimate)
Flash Point:	213.864oC
PSA:	46.01000
LogP:	2.48860

Synthetic route

Conditions	Yield
With water Flow reactor;	90%
Stage #1: phenazine methosulfate With water for 58.5h; Irradiation; Inert atmosphere; Stage #2: With sodium hydroxide In water for 36h; Inert atmosphere;	37%
Stage #1: phenazine methosulfate With water for 58.5h; Irradiation; Inert atmosphere; Stage #2: With sodium hydroxide In water for 36h; Inert atmosphere;	37%

Conditions	Yield
With hydrogen bromide; acetic acid In water for 8h; Reflux;	68%
With hydrogen bromide at 110 - 120℃;
With hydrogen bromide; acetic acid
With sodium methylate at 165℃;
With boron tribromide In dichloromethane

Conditions	Yield
With potassium hydroxide In methanol for 0.25h; Reflux;	37%

Conditions	Yield
With trifluoroacetic acid at 20℃;	37%

Conditions	Yield
With carbon monoxide; 1,3-bis-(diphenylphosphino)propane; 1,10-phenanthroline hydrate; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 120℃; under 4560.31 Torr; for 22h;	26%

Conditions	Yield
With phosphoric acid at 150 - 160℃;

Conditions	Yield
With sodium methylate at 165℃;
Multi-step reaction with 2 steps 1: methanol. sodium methylate / 140 °C 2: methanol. sodium methylate / 165 °C View Scheme

Conditions	Yield
With hydrogenchloride; water; tin(ll) chloride und Erhitzen des Reaktionsgemisches mit wss.HCl;
With hydrogenchloride; tin(ll) chloride Erhitzen des Reaktionsgemisches mit wss. HCl;