2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

Base Information

Chemical Name:2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine
CAS No.:737002-16-3
Molecular Formula:C₁₉H₂₀ClFN₄O₃
Molecular Weight:406.844
Hs Code.:

Synonyms:2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

Suppliers and Price of 2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

There total 6 articles about 2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 211739-59-2
2-(2-chloroethoxy)-4-chloro-6-nitrophenylamine

: 245762-27-0
3-(5-fluoro-1H-indol-3-yl)-propylamine

: 737002-16-3
2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 90 ℃; for 12h;
DOI:10.1021/jm0304010

Reference yield:

: 191013-68-0
3-(3-Bromopropyl)-5-fluoro-1H-indole

: 737002-16-3
2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / NaN₃ / dimethylformamide / 18 h / 60 °C

2: 61 percent / H₂ / Pd/C / ethanol / 16 h / 2585.74 Torr

3: 50 percent / Et₃N / dimethylsulfoxide / 12 h / 90 °C

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0304010

Reference yield:

: 141071-80-9
3-(5-fluoro-1H-indol-3-yl)propan-1-ol

: 737002-16-3
2-{2-[3-(5-fluoro-1H-indol-3-yl)propylamino]ethoxy}-4-chloro-6-nitrophenylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / CBr₄; Ph₃P / CH₂Cl₂ / 2 h

2: 89 percent / NaN₃ / dimethylformamide / 18 h / 60 °C

3: 61 percent / H₂ / Pd/C / ethanol / 16 h / 2585.74 Torr

4: 50 percent / Et₃N / dimethylsulfoxide / 12 h / 90 °C

With sodium azide; carbon tetrabromide; hydrogen; triethylamine; triphenylphosphine; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0304010