4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

Base Information

• Chemical Name: 4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
• CAS No.: 1339803-61-0
• Molecular Formula: C₂₀H₂₃N₅O₃
• Molecular Weight: 381.434

Synonyms:4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

Chemical Property of 4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

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Technology Process of 4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

There total 1 articles about 4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

C19H25N5O3 (1339803-88-1) + formamidine acetic acid (3473-63-0) → 4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one (1339803-61-0)

Guidance literature:

In propan-1-ol; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/jm200944b

Reference yield: 62.0%

6-azidohexyl 4-bromobenzenesulfonate (1339803-98-3) + 4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one (1339803-61-0) → 1-(6-azidohexyl)-4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one (1339803-93-8)

Guidance literature:

4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one; With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 1h; Inert atmosphere;

6-azidohexyl 4-bromobenzenesulfonate; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;

DOI:10.1021/jm200944b

Reference yield: 60.0%

4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one (1339803-61-0) + hex-3-yn-1-yl 4-methylbenzenesulfonate (51721-35-8) → 1-(hex-3-ynyl)-4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one (1339803-92-7)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm200944b

upstream raw materials:

C₁₉H₂₅N₅O₃

formamidine acetic acid

Downstream raw materials:

cis-(2S,4R)-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(6-(4-benzoylphenoxy)hexyl)-3H-1,2,4-triazol-3-one

1-(6-(4-benzoylphenoxy)hexyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

1-(6-azidohexyl)-4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

1-(6-(4-benzoylphenoxy)hexyl)-4-(4-(4-(4-(methoxymethoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

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