phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate

Base Information

• Chemical Name: phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate
• CAS No.: 1143463-44-8
• Molecular Formula: C₃₆H₃₅F₃N₄O₃
• Molecular Weight: 628.694

Synonyms:phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate

Chemical Property of phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate

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Technology Process of phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate

There total 1 articles about phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate (1143463-16-4) + 1,2,3,4-tetrahydro-2-methylquinoline (1780-19-4) → phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate (1143463-44-8)

Guidance literature:

In N,N-dimethyl-formamide; at 100 - 130 ℃; for 0.75h; microwave irradiation;

Reference yield:

phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate (1143463-44-8) → 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoic acid (1143463-45-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 25 ℃; under 2585.81 Torr;

upstream raw materials:

phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate

1,2,3,4-tetrahydro-2-methylquinoline

Downstream raw materials:

3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoic acid

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