phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate

Base Information

• Chemical Name: phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate
• CAS No.: 1143463-16-4
• Molecular Formula: C₂₆H₂₂F₃N₃O₃
• Molecular Weight: 481.474

Synonyms:phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate

Chemical Property of phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate

Chemical Property:

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Technology Process of phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate

There total 1 articles about phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylmethyl 3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propyl]amino}-1H-indazol-1-yl)benzoate (1142945-11-6) → phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate (1143463-16-4)

Guidance literature:

With polymer supported carbonate resin; In tetrahydrofuran; for 18h; Molecular sieve;

Reference yield:

1,2,3,4-tetrahydroisoquinoline (635-46-1) + phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate (1143463-16-4) → phenylmethyl 3-(4-{[2-(3,4-dihydro-1(2H)-quinolinylmethyl)-3,3,3-trifluoro-2-hydroxypropyl]amino}-6-methyl-1H-indazol-1-yl)benzoate (1143463-40-4)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 0.5h; microwave irradiation;

Reference yield:

phenylmethyl 3-[6-methyl-4-({[2-(trifluoromethyl)-2-oxiranyl]methyl}amino)-1H-indazol-1-yl]benzoate (1143463-16-4) + 1,2,3,4-tetrahydro-2-methylquinoline (1780-19-4) → phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate (1143463-44-8)

Guidance literature:

In N,N-dimethyl-formamide; at 100 - 130 ℃; for 0.75h; microwave irradiation;

upstream raw materials:

phenylmethyl 3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)propyl]amino}-1H-indazol-1-yl)benzoate

Downstream raw materials:

phenylmethyl 3-{6-methyl-4-[(3,3,3-trifluoro-2-hydroxy-2-{[(1-methylethyl)(phenyl)amino]methyl}propyl)amino]-1H-indazol-1-yl}benzoate

phenylmethyl 3-(4-{[2-(3,4-dihydro-1(2H)-quinolinylmethyl)-3,3,3-trifluoro-2-hydroxypropyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

phenylmethyl 3-[6-methyl-4-({3,3,3-trifluoro-2-hydroxy-2-[(2-methyl-3,4-dihydro-1(2H)-quinolinyl)methyl]propyl}amino)-1H-indazol-1-yl]benzoate

phenylmethyl 3-{4-[(2-{[bis(1-methylethyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)amino]-6-methyl-1H-indazol-1-yl}benzoate

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