2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

Base Information

Chemical Name:2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan
CAS No.:270924-37-3
Molecular Formula:C₃₂H₃₄O₅
Molecular Weight:498.619
Hs Code.:

Synonyms:2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

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Chemical Property of 2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

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Technology Process of 2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

There total 6 articles about 2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 270924-36-2
2-[1-D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

: 74-88-4
methyl iodide

: 270924-37-3
2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/S0957-4166(99)00479-6

Reference yield:

: 4356-77-8,35094-65-6,61277-56-3,65556-30-1,78185-13-4,78185-15-6,109958-31-8,109958-33-0,113532-02-8,59433-13-5
1,6-di-O-acetyl-2,3,4-tri-O-benzyl-D-glucopyranose

: 270924-37-3
2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / TMSOTf / acetonitrile / -40 - -20 °C

2: 91 percent / MeONa / methanol / 2 h / 20 °C

3: 89 percent / I₂; imidazole; PPh₃ / toluene / 0.5 h / 70 °C

4: 72 percent / NaH / dimethylformamide / 2 h / 20 °C

5: 83 percent / TIBAL / toluene / 0.5 h / 50 °C

6: 96 percent / NaH / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; iodine; triisobutylaluminum; sodium methylate; sodium hydride; triphenylphosphine; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile; 1: C-glycosylation / 2: Deacetylation / 3: Iodination / 4: Dehydroiodination / 5: Rearrangement / 6: Methylation;
DOI:10.1016/S0957-4166(99)00479-6

Reference yield:

: 270924-32-8
2-(2,3,4-tri-O-benzyl-6-deoxy-α-D-xylo-hex-5-enopyranosyl)furan

: 270924-37-3
2-[1D-(1,2,4,5/3)-2,3,4-tri-O-benzyl-5-O-methyl-2,3,4,5-tetrahydroxy-cyclohexyl]furan

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / TIBAL / toluene / 0.5 h / 50 °C

2: 96 percent / NaH / dimethylformamide / 1 h / 20 °C

With triisobutylaluminum; sodium hydride; In N,N-dimethyl-formamide; toluene; 1: Rearrangement / 2: Methylation;
DOI:10.1016/S0957-4166(99)00479-6