5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid

Base Information

• Chemical Name: 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid
• CAS No.: 79623-04-4
• Molecular Formula: C₁₃H₁₈O₅
• Molecular Weight: 254.283
• Mol file: 79623-04-4.mol

Synonyms:5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid

Chemical Property of 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid

There total 4 articles about 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.5%

5-(3,4-dimethoxyphenyl)pentanoic acid (1145-15-9) → 5-hydroxy-5-(3,4-dimethoxyphenyl)valeric acid δ lactone (79623-03-3) + 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid (79623-04-4)

Guidance literature:

With boron trifluoride diethyl etherate; thallium(III) trifluoroacetate; In dichloromethane; trifluoroacetic acid; at -20 ℃; for 0.00555556h;

DOI:10.1021/ja00413a013

Reference yield:

glutaric anhydride, (108-55-4) → 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid (79623-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium chloride; nitrobenzene

2: amalgamated zinc; aqueous hydrochloric acid; toluene

With hydrogenchloride; aluminium trichloride; amalgamated zinc; nitrobenzene; toluene;

DOI:10.1039/jr9480001045

Reference yield:

1,2,3-trimethoxybenzene (634-36-6) → 5-(3,4-dimethoxy-2-hydoxyphenyl)valeric acid (79623-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium chloride; nitrobenzene

2: amalgamated zinc; aqueous hydrochloric acid; toluene

With hydrogenchloride; aluminium trichloride; amalgamated zinc; nitrobenzene; toluene;

DOI:10.1039/jr9480001045

upstream raw materials:

5-(2,3,4-trimethoxy-phenyl)-5-oxo-pentanoic acid

5-(3,4-dimethoxyphenyl)pentanoic acid

glutaric anhydride,

1,2,3-trimethoxybenzene

Downstream raw materials:

5-(2',3',4'-trimethoxyphenyl)pentanoic acid