5-(3,4-dimethoxyphenyl)pentanoic acid

Base Information

• Chemical Name: 5-(3,4-dimethoxyphenyl)pentanoic acid
• CAS No.: 1145-15-9
• Molecular Formula: C13H18 O4
• Molecular Weight: 238.284
• Hs Code.: 2918990090
• Mol file: 1145-15-9.mol

Synonyms:Valericacid, 5-(3,4-dimethoxyphenyl)- (6CI,7CI,8CI); 5-(3,4-Dimethoxyphenyl)pentanoicacid; 5-(3,4-Dimethoxyphenyl)valeric acid; NSC 46662

Chemical Property of 5-(3,4-dimethoxyphenyl)pentanoic acid

Chemical Property:

• Vapor Pressure: 6.02E-07mmHg at 25°C
• Melting Point: 75-77 °C
• Boiling Point: 394.9°C at 760 mmHg
• PKA: 4.74±0.10(Predicted)
• Flash Point: 147.5°C
• PSA: 55.76000
• Density: 1.111g/cm³
• LogP: 2.50120

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(3,4-DIMETHOXYPHENYL)PENTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3,4-dimethoxyphenyl)pentanoic acid

There total 18 articles about 5-(3,4-dimethoxyphenyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

malonic acid (141-82-2) + 3-(3,4-Dimethoxyphenyl)propanal (61871-67-8) → 5-(3,4-dimethoxyphenyl)pentanoic acid (1145-15-9)

Guidance literature:

malonic acid; 3-(3,4-Dimethoxyphenyl)propanal; With piperidine; pyridine; Reflux;

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; under 760.051 Torr;

DOI:10.1002/ddr.21782

Reference yield: 90.0%

5-(3,4-dimethoxy-phenyl)-5-oxo-pentanoic acid (4378-55-6) → 5-(3,4-dimethoxyphenyl)pentanoic acid (1145-15-9)

Guidance literature:

With hydrogenchloride; acetic acid; mercury; zinc; In water; toluene; for 16h; Heating;

Reference yield: 88.0%

(E)-5-(3,4-dimethoxyphenyl)pent-4-enoic acid → 5-(3,4-dimethoxyphenyl)pentanoic acid (1145-15-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02851

upstream raw materials:

5-(3,4-dimethoxy-phenyl)-5-oxo-pentanoic acid

glutaric anhydride,

1,2-dimethoxybenzene

(3-(3,4-Dimethoxy-phenyl)-allyliden)-malonsaeure

Downstream raw materials:

5-(3,4-dimethoxyphenyl)pentanoic acid ethyl ester

5-(3′,4′,5′-trihydroxyphenyl)valeric acid

1,2-dimethoxy-4-(5-hydroxypentyl)benzene

6-(3,4-dimethoxyphenyl)-1,1,1-trifluorohexan-2-one

Refernces

• 1、 Kurouchi, Hiroaki,Ohwada, Tomohiko. "Synthesis of Medium-Ring-Sized Benzolactams by Using Strong Electrophiles and Quantitative Evaluation of Ring-Size Dependency of the Cyclization Reaction Rate". . p. 876 - 901. Retrieved 2019/12/30.
• 2、 Motiwala, Hashim F.,Vekariya, Rakesh H.,Aubé, Jeffrey. "Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol". . p. 5484 - 5487. Retrieved 2015/11/18.