2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone

Base Information

• Chemical Name: 2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone
• CAS No.: 884195-05-5
• Molecular Formula: C₂₀H₁₉NO₃
• Molecular Weight: 321.376
• Mol file: 884195-05-5.mol

Synonyms:2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone

Chemical Property of 2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone

There total 1 articles about 2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,4,4-trimethyl oxazoline (1772-43-6) + benzoyl chloride (98-88-4) → 2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone (884195-05-5)

Guidance literature:

With triethylamine; In acetonitrile; for 3h; Heating;

DOI:10.1246/bcsj.57.2329

Reference yield: 93.0%

2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone (884195-05-5) → 2-(β-hydroxystyryl)-4,4-dimethyl-2-oxazoline (93074-93-2)

Guidance literature:

With potassium hydroxide; In methanol; for 6h; Ambient temperature;

DOI:10.1246/bcsj.57.2329

Reference yield:

2-[3-Benzoyl-4,4-dimethyl-oxazolidin-(2E)-ylidene]-1-phenyl-ethanone (884195-05-5) → (Z)-2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-1-phenyl-but-1-en-1-ol

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / KOH / methanol / 6 h / Ambient temperature

2: 1) C₂H₅ONa / 1) C₂H₅OH, 2) DMF, room temperature

With potassium hydroxide; sodium ethanolate; In methanol;

DOI:10.1246/bcsj.57.2329

upstream raw materials:

2,4,4-trimethyl oxazoline

benzoyl chloride

Downstream raw materials:

2-(β-hydroxystyryl)-4,4-dimethyl-2-oxazoline

2-(β-hydroxy-α-methylstyryl)-4,4-dimethyl-2-oxazoline