4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid

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Chemical Name:4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid
CAS No.:1402888-96-3
Molecular Formula:C₂₆H₃₈N₂O₅S
Molecular Weight:490.664
Hs Code.:

Synonyms:4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid

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Chemical Property of 4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid

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Technology Process of 4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid

There total 12 articles about 4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1402888-95-2
Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

: 1402888-96-3
4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid

Guidance literature:: With methanol; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 3284-51-3
ethyl 5-methyl-1H-pyrrole-2-carboxylate

: 1402888-96-3
4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

1.2: 50 °C

2.1: chlorosulfonic acid / 36 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / ethanol; water / Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 7 h / 20 °C / Reflux; Inert atmosphere

6.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

7.1: lithium hydroxide; methanol / tetrahydrofuran / 20 °C

With hydrogenchloride; methanol; chlorosulfonic acid; N-Bromosuccinimide; potassium carbonate; caesium carbonate; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1402888-96-3
4-(3-(tert-Butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide / N,N-dimethyl-formamide / 3 h / 80 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Sealed vial

3: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

4: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 7 h / 20 °C / Reflux; Inert atmosphere

5: caesium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

6: lithium hydroxide; methanol / tetrahydrofuran / 20 °C

With methanol; copper(l) iodide; potassium acetate; boron tribromide; caesium carbonate; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki Coupling / 4: Suzuki Coupling;