Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

Base Information

Chemical Name:Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate
CAS No.:1402888-95-2
Molecular Formula:C₂₇H₄₀N₂O₅S
Molecular Weight:504.691
Hs Code.:

Synonyms:Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

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Chemical Property of Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

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Technology Process of Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

There total 11 articles about Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 4897-84-1
Methyl 4-bromobutyrate

: 1402888-94-1
5-(3-(tert-Butyl)-5-hydroxyphenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

: 1402888-95-2
Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 1402888-95-2
Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide / N,N-dimethyl-formamide / 3 h / 80 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Sealed vial

3: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

4: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 7 h / 20 °C / Reflux; Inert atmosphere

5: caesium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

With copper(l) iodide; potassium acetate; boron tribromide; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki Coupling / 4: Suzuki Coupling;

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1402888-95-2
Methyl 4-(3-(tert-butyl)-5-(1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrol-2-yl)phenoxy)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

1.2: 50 °C

2.1: chlorosulfonic acid / 36 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / ethanol; water / Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 7 h / 20 °C / Reflux; Inert atmosphere

6.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

With hydrogenchloride; chlorosulfonic acid; N-Bromosuccinimide; potassium carbonate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;