1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate

Base Information

• Chemical Name: 1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate
• CAS No.: 195518-79-7
• Molecular Formula: C₂₀H₂₈F₂O₆
• Molecular Weight: 402.436
• Mol file: 195518-79-7.mol

Synonyms:1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate

Chemical Property of 1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate

There total 2 articles about 1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Benzyloxyacetyl chloride (19810-31-2) + 1,1-Difluoro-2-(2-methoxy-ethoxymethoxy)-4,4-dimethyl-pent-1-en-3-ol (170941-67-0) → 1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate (195518-79-7)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1039/b004766j

Reference yield:

2-((2-(methoxy)ethoxy)methoxy)-1,1,1-trifluoroethane (130156-55-7) → 1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate (195518-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / -78 °C

2: 67 percent / DMAP, pyridine, DCM / 0 °C

With pyridine; dmap; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(97)01315-4

Reference yield:

1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate (195518-79-7) → (Z)-2-Benzyloxy-3,3-difluoro-4-(2-methoxy-ethoxymethoxy)-6,6-dimethyl-hept-4-enoic acid

Guidance literature:

1,1-Difluoro-2-[(2-methoxyethoxy)methoxy]-4,4-dimethylpent-1-en-3-yl (benzyloxy)acetate; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

With methanol; In tetrahydrofuran; at 20 ℃; for 0.25h; Further stages.;

DOI:10.1039/b004766j

upstream raw materials:

Benzyloxyacetyl chloride

1,1-Difluoro-2-(2-methoxy-ethoxymethoxy)-4,4-dimethyl-pent-1-en-3-ol

2-((2-(methoxy)ethoxy)methoxy)-1,1,1-trifluoroethane