1,1,1-Trifluoro-2-[(2-methoxyethoxy)methoxy]ethane

Base Information

• Chemical Name: 1,1,1-Trifluoro-2-[(2-methoxyethoxy)methoxy]ethane
• CAS No.: 130156-55-7
• Molecular Formula: C6H11F3O3
• Molecular Weight: 188.147
• DSSTox Substance ID: DTXSID90450419
• Nikkaji Number: J755.913E
• Wikidata: Q82270137
• Mol file: 130156-55-7.mol

Synonyms:1,1,1-trifluoro-2-[(2-methoxyethoxy)methoxy]ethane;130156-55-7;1,1,1-trifluoro-2-(2-methoxyethoxymethoxy)ethane;1,1,1-Trifluoro-2-[(2-Methoxyethoxy)Methoxy]-ethane;C6H11F3O3;SCHEMBL2872304;DTXSID90450419;VELOOMPEOHFDNC-UHFFFAOYSA-N;MFCD18325133;AKOS015949175;FT-0685120;2,2,2-Trifluoroethyl(2-methoxyethoxymethyl) ether;J-503695;1,1,1-trifluoro-2-(2-methoxy-ethoxy-methoxy)-ethane;1,1,1-Trifluoro-2-(2-methoxy-ethoxymethoxy)-ethane

Chemical Property of 1,1,1-Trifluoro-2-[(2-methoxyethoxy)methoxy]ethane

Chemical Property:

• PSA: 27.69000
• LogP: 1.18580
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 188.06602869
• Heavy Atom Count: 12
• Complexity: 105

Purity/Quality:

98%min ^*data from raw suppliers

1,1,1-Trifluoro-2-[(2-methoxyethoxy)methoxy]ethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCOCC(F)(F)F

Technology Process of 1,1,1-Trifluoro-2-[(2-methoxyethoxy)methoxy]ethane

There total 1 articles about 1,1,1-Trifluoro-2-[(2-methoxyethoxy)methoxy]ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,2,2-trifluoroethanol (75-89-8) + 2-Methoxyethoxymethyl chloride (3970-21-6) → 2-((2-(methoxy)ethoxy)methoxy)-1,1,1-trifluoroethane (130156-55-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; toluene; 0 deg C, 1 h; RT, overnight;

DOI:10.1016/0040-4020(95)00525-D

Reference yield: 77.0%

2-((2-(methoxy)ethoxy)methoxy)-1,1,1-trifluoroethane (130156-55-7) + cyclohexanecarbaldehyde (2043-61-0) → C13H22F2O4

Guidance literature:

2-((2-(methoxy)ethoxy)methoxy)-1,1,1-trifluoroethane; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

cyclohexanecarbaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 18h;

DOI:10.1021/acs.joc.8b01121

Reference yield: 76.0%

2-((2-(methoxy)ethoxy)methoxy)-1,1,1-trifluoroethane (130156-55-7) + 4-methoxy-benzaldehyde (123-11-5) → 3,3-Difluoro-2-(2-methoxy-ethoxymethoxy)-1-(4-methoxy-phenyl)-prop-2-en-1-ol (130156-57-9)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.) -78 deg C, 0.5 h; 2.) -78 to -30 deg C;

DOI:10.1016/0040-4020(95)00525-D

upstream raw materials:

2,2,2-trifluoroethanol

2-Methoxyethoxymethyl chloride

Downstream raw materials:

3,3-Difluoro-2-(2-methoxy-ethoxymethoxy)-1-(4-methoxy-phenyl)-prop-2-en-1-ol

3,3-Difluoro-2-(2-methoxy-ethoxymethoxy)-1-phenyl-prop-2-en-1-ol

4,4-Difluoro-3-[(2-methoxyethoxy)methoxy]but-3-en-2-yl (benzyloxy)acetate

2-Benzyloxy-3,3-difluoro-4-[(2-methoxyethoxy)methoxy]hex-4-enoic acid

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